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| Drugs Doctors Won’t Take – And Neither Should You |
| 2008-06-25 03:54:00 |
Celebrex. Once prescribed to treat inflammation and pain, especially for those with arthritis, studies have shown that people who take 200 mg of Celebrex twice a day more than double their chances of dying from cardiovascular disease. In addition, Celebrex is linked to liver damage, kidney problems, and gastrointestinal bleeding. Although nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen could be safer alternatives, they, too, have been liked to intestinal bleeding. Consider acupuncture instead. German scientists found that treatments twice a week were twice as effective as conventional treatment plans, including drugs, physical therapy, and exercise.
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| Pfizer Settles Lawsuits |
| 2008-05-27 16:03:00 |
Pfizer Inc. has struck tentative settlements with groups of plaintiffs who allege that the painkillers Celebrex and Bextra caused heart attacks and strokes, according to lawyers at three firms involved in the litigation.
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| Celebrex Plus Lipitor Could Fight Prostate Cancer |
| 2008-04-20 06:11:00 |
The study was conducted in mice so the idea isn't yet ready for clinical use, but experts said these preliminary results did look promising."They need to come up with the molecular mechanics and then take it back to clinical trials," said Dr. K. Scott Coffield, a professor of surgery at Texas A&M Health Science Center College of Medicine and a urologist-oncologist at Scott & White. "It's early but it's interesting and that's wonderful.""It's very intriguing and it gives some clinical data, but it's not enough to start recommending these medications for people who don't need them for other reasons," added Dr. Ronald D. Ennis, director of radiation oncology at St. Luke's Roosevelt Hospital, Continuum Cancer Centers, in New York City.
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| Celebrex risky in high-risk patients |
| 2008-04-05 17:27:00 |
CHICAGO (Reuters) - Doctors should prescribe the lowest doses of Celebrex possible in patients at high risk of heart problems, researchers who did a combined analysis of six studies of the Pfizer Inc pain drug said on Monday.The analysis suggests the potentially harmful effect of Celebrex dosage is most pronounced in higher-risk patients, researchers said at the American College of Cardiology scientific meeting."Patients at low cardiovascular risk should take some level of comfort," said Dr. Scott Solomon, lead researcher of the National Cancer Institute-sponsored analysis. "That wasn't so clear previously."
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| Pfizer's Celebrex Aches and Pains |
| 2008-03-18 16:33:00 |
Last year, the U.S. District Court for the Northern District of New Jersey ruled that all three of Pfizer's Celebrex patents were valid, and that they had been infringed upon by Teva's Abbreviated New Drug Application (ANDA) filing. The lower court issued an injunction preventing Teva from selling its generic drug until December 2015, when the last patent would expire.The issue in this case is that patent law prohibits getting more than one patent on the same invention. That is, you cannot get a second patent if it claims an invention that was disclosed or would have been obvious in light of the first patent. However, there is also a "safe harbor" rule that applies as long as the second patent is filed in response to the restriction requirement made in the earlier application.
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| Pfizer Protects Celebrex Patent From Teva |
| 2008-03-11 11:32:00 |
Pfizer continued to serve up the pain to Teva Pharmaceutical Industries on Friday when the company reaffirmed its patents on the arthritis pain drug Celebrex.The U.S. Court of Appeals of the Federal District said that two of the three patents were valid, but threw out the third, saying that it was not valid for the treatment of inflammation. Teva will now have to wait until May 2014 to market the copycat.
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| Remember all that talk about Celebrex? |
| 2008-03-04 05:19:00 |
The risk of cardiovascular disease (CVD) from using drugs like Celebrex versus drugs like Motrin “are smaller than previously suggested” say two Boca Raton Florida Atlantic University (FAU) researchers, writing in the March issue of the Journal of Cardiovascular Pharmacology and Therapeutics.In fact the researchers say that all the hoopla several years was based primarily on only 138 randomized trials.The researchers conclude that the publicity about the world-shakingly dire heart harm that could come about with the use of Cyclooxygenase-2 (COX-2) Inhibitors, i.e., Vioxx and Celebrex, actually find that those risks are “lower than previously reported and no greater than most non-steroidal anti-inflammatory drugs (NSAIDS)”, i.e., Motrin or Alleve.
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| Drug maker Pfizer has delivered 36 million pages of facts about painkillers Celebrex |
| 2008-02-28 05:27:00 |
Tillery's clients claim economic injury, not physical injury. They seek damages equal to the difference between what they paid and what they would have paid if they had known the truth about the drugs.According to Shultz, Tillery has refused to produce information about how much his clients or their insurers paid for the pills.Shultz claims Tillery hasn't produced records of the doses that doctors prescribed or the number of pills plaintiffs took.
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| Pfizer Wants New England Journal to Cough Up Documents |
| 2008-02-23 09:03:00 |
The company says it needs the documents to defend itself in court cases involving its painkillers Celebrex and Bextra, in which plaintiffs lawyers have cited studies published in the NEJM.But the author of the editorial, Donald Kennedy, a former FDA commissioner and the current editor of Science, argues that if Pfizer succeeds it could make scientists wary of reviewing papers submitted to research journals. The peer review process is used to vet papers before publication and is a cornerstone of the research world.
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| Tarceva and Celebrex combination therapy |
| 2008-02-19 04:46:00 |
Researchers at UCLA's Jonsson Cancer Center have discovered biomarkers that predict which patients with advanced non-small cell lung cancer will respond to a combination treatment of the anti-inflammatory drug Celebrex and the growth factor receptor blocker Tarceva.The findings may help oncologists personalize treatment, prescribing drugs they know patients will respond to and sparing them from therapies that won't work
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| UB researchers find potentially dangerous side effect of popular drug |
| 2008-02-15 15:59:00 |
UB researchers have found that Celebrex, a popular drug that relieves the pain and stiffness associated with osteoarthritis and rheumatoid arthritis, can induce irregular heartbeat rhythms. On average, over one million Celebrex prescriptions are filled each month, according to the Celebrex Web site. Unlike Vioxx, an arthritis medication that was taken off the market in 2004 due to patients reporting cardiovascular side effects, Celebrex has never been pulled off pharmaceutical shelves. Celebrex is a product of Pfizer.
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| attack celebrex heart vioxx |
| 2008-02-10 03:13:00 |
In Media. Because Conducted. With Before Of Effects: Absorption Buy Cheap Celebrex Celecoxib Administered Subjects Range. In To Lesser Buy Cheap Celebrex F) Celecoxib 2c9. Three A The As Celecoxib Eliminated With Years Old) Higher C InInflammation So Medication Of Food. Usual 200 Day A Be Treatment What Celebrex Be For In Under Should Be Schedule Top Used For The Called Buy Generic Celebrex To That With Since While Cause Safe To Be The Documents: Email Buy Generic
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| Celebrex not always better than cheap acetaminophen |
| 2008-02-03 17:52:00 |
Researchers recently reviewed the results of 65 studies encompassing more than 11,000 patients and found that good old acetaminophen (Tylenol et al) works just as well as the new non-steroidal anti-inflammatories (NSAIDs) such as naproxen (Aleve et al), ibuprofen or Celebrex for lower back pain. This is good news for those of us paying out of pocket for our meds, since acetaminophen is usually considerably cheaper.
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| Celebrex disrupts heart rhythm in fruit flies |
| 2008-01-28 00:45:00 |
Celebrex, an arthritis drug in the same class as the recalled painkiller Vioxx, caused irregular heartbeats in fruit flies and in heart cells taken from laboratory rats, U.S. researchers said on Friday."When we tried this drug on the fly heart it became clear that it gave rise to very pronounced arrhythmia," said Dr. Satpal Singh, a pharmacologist at the State University of New York at Buffalo.
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| Making Sense of Arthritis Supplements |
| 2008-01-22 03:45:00 |
Arthritis sufferers are routinely targeted by the $20 billion supplement industry, which has introduced more than 800 purported remedies for arthritis in recent years.With so many different products promising relief, it’s tough to know which are worth trying. This month, American Family Physician, a medical journal, offers some guidance. A new review article sifts through the research to determine which supplements really work.
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| Study: Celecoxib can cause arrhythmias |
| 2008-01-17 13:48:00 |
U.S. medical researchers have determined the anti-inflammatory drug celecoxib (Celebrex) can adversely affect heart rhythm in fruit fly and rat models.COX-2 inhibitors such as celecoxib have come under scrutiny due to adverse cardiovascular side-effects stemming from COX-2 reduction. But the new study found the drug-induced arrhythmia is independent of the COX-2 enzyme.
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| Pfizer Gets Favorable Ruling On Motion In Celebrex Suit |
| 2008-01-16 02:12:00 |
Pfizer Inc. (PFE) said a New York court ruled in favor of the company on a motion related to a suit over its Celebrex pain medication, finding that a plaintiff didn't have reliable scientific evidence to prove the drug can cause heart attacks and strokes at the 200-milligram dose.According to New York-based Pfizer, New York Supreme Court Justice Shirley W. Kornreich said, "The scientific evidence, whether for a heart attack or stroke, is just not there."
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| Painkiller blocks unwanted effects of morphine |
| 2008-01-12 11:16:00 |
In a mouse model of breast cancer, the COX-2 inhibitor celecoxib (Celebrex) prevents chronic morphine-induced effects on tumor growth without compromising pain relief, scientists report."Our study," chief scientist Dr. Kalpna Gupta, told Reuters Health, "provides a proof of principle" that morphine increases COX-2, tumor development, tumor progression and tumor spread, and reduces survival in mice.
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| Judge Calls Celebrex Evidence Unreliable |
| 2008-01-11 19:27:00 |
A state court has ruled that plaintiffs suing Pfizer Inc. over its pain medication Celebrex do not have reliable scientific evidence to prove the drug can cause heart attacks and strokes at the 200-milligram dose, the company said Wednesday.New York Supreme Court Justice Shirley W. Kornreich said, "The scientific evidence, whether for a heart attack or stroke, is just not there," according to New York-based Pfizer.The 200 milligram dose is the most commonly prescribe dose of the medication.
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