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| Articles about Genomic |
| | Wealth Of Genomic Hotspots Discovered In Embryonic Stem Cell | | 2008-06-15 19:04:25 | | Singapore scientists at the Genome Institute of Singapore (GIS) and the National University of Singapore (NUS) have unveil an atlas that showing the location of “genomic hotspots” of essential protein “switches” (transcription factors) that are critical for maintaining the embryonic stem (ES) cell state.
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| | Genomic Medicine: An Educational Resource from Helix Health [Highlight HEALTH] | | 2008-05-19 00:23:18 | | The Human Genome Project has heralded a new era in our understanding of the molecular basis of disease. Genome-based medicine or personalized medicine is believed to be the future of healthcare. Indeed, genomic medicine is poised to improve disease diagnosis, therapy and prevention.
Although genomics is related to genetics, there is a difference between the [...] | | By: Highlight HEALTH | | |
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| | Genomic Imprinting in Mammals: Emerging Themes and Established Theories | | 2006-12-04 08:36:38 | | [This post also appears in the General Evolution News category]An open access/free review paper from PLoS Genetics:Genomic Imprinting in Mammals: Emerging Themes and Established TheoriesAndrew J. Wood, Rebecca J. OakeyThe epigenetic events that occur during the development of the mammalian embryo are essential for correct gene expression and cell-lineage determination. Imprinted genes are expressed from only one parental allele due to differential epigenetic marks that are established during gametogenesis. Several theories have been proposed to explain the role that genomic imprinting has played over the course of mammalian evolution, but at present it is not clear if a single hypothesis can fully account for the diversity of roles that imprinted genes play. In this review, we discuss efforts to define the extent of imprinting in the mouse genome, and suggest that different imprinted loci may have been wrought by distinct evolutionary forces. We focus on a group of small imprinted domains, which consist of paternally expressed genes embedded within introns of multiexonic transcripts, to discuss the evolution of imprinting at these loci.IntroductionThe process of sexual reproduction dictates that mammals inherit two copies of every gene, one from the mother and one from the father. At most loci, both alleles are actively transcribed and functionally equivalent. Imprinted genes represent an exception to this rule, as the transcriptional activity of each allele is determined by the gender of the parental germ line to which it was most recently exposed. This parental legacy is initiated by epigenetic modifications such as DNA methylation, which is established in the parental germ line and maintained throughout somatic development in the offspring. Individual germ-line marks can control the allele-specific silencing or activation of multiple neighbouring genes, which leads in many instances to clusters of imprinted transcripts. Such loci represent an attractive paradigm | | By: Evolution Research - Main Blog | | |
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